Sarah Samorodnitsky

Nov 1, 2024 | dx.doi.org | Sarah Samorodnitsky |Michael Wu

http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial.

Sep 10, 2024 | respiratory-research.biomedcentral.com | Sarah Samorodnitsky |Eric F Lock |Ken Kunisaki |Alison Morris |Janice M. Leung |Subina Mehta | +6 more

PLWH who had undergone bronchoscopy were selected from the Pittsburgh and Vancouver Lung HIV Cohorts [15, 16]. This consisted of individuals (n = 25) with OLD as defined as the ratio of forced expiratory volume in 1-s/forced vital capacity (FEV1/FVC) < lower limit of normal.

Mar 13, 2024 | biorxiv.org | Sarah Samorodnitsky |Katie Campbell |Antoni Ribas |Michael Wu

AbstractSpatial proteomics can reveal the spatial organization of immune cells in the tumor immune microenvironment. Relating measures of spatial clustering, such as Ripley's K or Besag's L, to patient outcomes may offer important clinical insights. However, these measures require pre-specifying a radius in which to quantify clustering, yet no consensus exists on the optimal radius which may be context-specific.

Mar 1, 2023 | openres.ersjournals.com | Sarah Samorodnitsky |Eric F Lock |Alison Morris |Janice M. Leung

DiscussionWe found that the BALF proteome in persons living with HIV distinguishes those with obstructive lung disease from those without obstructive lung disease. However, we did not identify any pathways composed of proteins that were differentially expressed among individuals with high FEV1 % pred and those with low FEV1 % pred. We did identify an endotype driven by both proteomic and metabolomic BALF molecular contributors, but not plasma metabolites.