Eric Small

2 days ago | nature.com | Christy Steadman |Eric Small

AbstractMicroalgae remain an important feedstock in the circular bioeconomy. The discovery of new species combined with advanced biotechnology drives optimization of performance predicated on deep knowledge of algal genomics and phenotype. Understanding the contribution of epigenetic processes to algal function provides insight and better approaches for achieving production goals.

Nov 22, 2024 | biorxiv.org | Eric Small |Christy Steadman

AbstractEpigenetic processes play key roles in regulating gene expression, genome stability, and metabolic output in organisms across the tree of life. Yet, the role epigenetics plays in regulating genomes and behaviors remains underdeveloped for microalgae, particularly as new species are identified and characterized.

Aug 9, 2024 | mdpi.com | Clara Chew |Eric Small |Liza J. Wernicke

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Jul 19, 2024 | biorxiv.org | Vrinda Venu |Eric Small |Cullen Roth |Samantha H. Adikari

AbstractDysregulation of epigenetic processes leads to a plethora of abnormalities including disease states such as cancer. Therapies focused on epigenetic modulation alter gene expression to correct dysfunction, though the mechanisms and perpetuation of these states is unknown. Here, we use integrated epigenomics and three-dimensional chromatin structure-function analyses after acute histone deacetylase inhibitor cancer drug treatment (suberoylanilide hydroxamic acid in lung cancer cells).

Jun 10, 2024 | nature.com | Vrinda Venu |Cullen Roth |Eric Small |Shawn R Starkenburg |Karissa Y. Sanbonmatsu

AbstractThe genome folds into complex configurations and structures thought to profoundly impact its function. The intricacies of this dynamic structure-function relationship are not well understood particularly in the context of viral infection. To unravel this interplay, here we provide a comprehensive investigation of simultaneous host chromatin structural (via Hi-C and ATAC-seq) and functional changes (via RNA-seq) in response to vaccinia virus infection.