Fabian Bumbak

Jun 7, 2023 | nature.com | Asuka Inoue |Miquel Pons |Scott A. Robson |Daniel Scott |Paul Gooley |Fabian Bumbak | +1 more

AbstractThe neurotensin receptor 1 (NTS1) is a G protein-coupled receptor (GPCR) with promise as a drug target for the treatment of pain, schizophrenia, obesity, addiction, and various cancers. A detailed picture of the NTS1 structural landscape has been established by X-ray crystallography and cryo-EM and yet, the molecular determinants for why a receptor couples to G protein versus arrestin transducers remain poorly defined.