Scott A. Robson

May 16, 2024 | onlinelibrary.wiley.com | James B. Bower |Scott A. Robson |Joshua J. Ziarek

1 INTRODUCTION G protein-coupled receptors (GPCRs) comprise the largest protein family in eukaryotes—accounting for 3–4% of the human genome (Fredriksson et al., 2003). With over a third of FDA-approved drugs targeting GPCRs, it follows that these receptors possess considerable significance in human physiology and pathology (Hauser et al., 2017).

Jun 7, 2023 | nature.com | Asuka Inoue |Miquel Pons |Scott A. Robson |Daniel Scott |Paul Gooley |Fabian Bumbak | +1 more

AbstractThe neurotensin receptor 1 (NTS1) is a G protein-coupled receptor (GPCR) with promise as a drug target for the treatment of pain, schizophrenia, obesity, addiction, and various cancers. A detailed picture of the NTS1 structural landscape has been established by X-ray crystallography and cryo-EM and yet, the molecular determinants for why a receptor couples to G protein versus arrestin transducers remain poorly defined.