Paul Gooley

Nov 19, 2023 | nature.com | Eric Hanssen |Craig Morton |Michael Parker |Paul Gooley |Clara C. Kosasih

AbstractInterleukin (IL-)11, an IL-6 family cytokine, has pivotal roles in autoimmune diseases, fibrotic complications, and solid cancers. Despite intense therapeutic targeting efforts, structural understanding of IL-11 signalling and mechanistic insights into current inhibitors are lacking. Here we present cryo-EM and crystal structures of the human IL-11 signalling complex, including the complex containing the complete extracellular domains of the shared IL-6 family β-receptor, gp130.

Jun 7, 2023 | nature.com | Asuka Inoue |Miquel Pons |Scott A. Robson |Daniel Scott |Paul Gooley |Fabian Bumbak | +1 more

AbstractThe neurotensin receptor 1 (NTS1) is a G protein-coupled receptor (GPCR) with promise as a drug target for the treatment of pain, schizophrenia, obesity, addiction, and various cancers. A detailed picture of the NTS1 structural landscape has been established by X-ray crystallography and cryo-EM and yet, the molecular determinants for why a receptor couples to G protein versus arrestin transducers remain poorly defined.