Fabian Lim

Oct 18, 2023 | nature.com | Brandon J. Mannion |Dunja Knapp |Fabian Lim |Anna Czarkwiani |Viviana Hermosilla Aguayo |Licia Selleri | +6 more

AbstractThe cell type-specific expression of key transcription factors is central to development and disease. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning, and notochord formation; however, how its expression is controlled in the mammalian notochord has remained elusive. Here, we identify the complement of notochord-specific enhancers in the mammalian Brachyury/T/TBXT gene.