Brandon J. Mannion

Mar 20, 2024 | nature.com | Zhuoxin Chen |Valentina Snetkova |Benjamin Clock |Iros Barozzi |Brandon J. Mannion |Ana Alcaina-Caro | +3 more

AbstractRemote enhancers are thought to interact with their target promoters via physical proximity, yet the importance of this proximity for enhancer function remains unclear. Here we investigate the three-dimensional (3D) conformation of enhancers during mammalian development by generating high-resolution tissue-resolved contact maps for nearly a thousand enhancers with characterized in vivo activities in ten murine embryonic tissues.

Oct 18, 2023 | nature.com | Brandon J. Mannion |Dunja Knapp |Fabian Lim |Anna Czarkwiani |Viviana Hermosilla Aguayo |Licia Selleri | +6 more

AbstractThe cell type-specific expression of key transcription factors is central to development and disease. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning, and notochord formation; however, how its expression is controlled in the mammalian notochord has remained elusive. Here, we identify the complement of notochord-specific enhancers in the mammalian Brachyury/T/TBXT gene.