Farshad Nassiri

May 10, 2023 | nature.com | Yasin Mamatjan |Olivia Singh |Farshad Nassiri |Trevor J. Pugh |Gary D. Bader |Kenneth Aldape | +4 more

AbstractMalignant peripheral nerve sheath tumor (MPNST) is a highly aggressive sarcoma, and a lethal neurofibromatosis type 1-related malignancy, with little progress made on treatment strategies. Here, we apply a multiplatform integrated molecular analysis on 108 tumors spanning the spectrum of peripheral nerve sheath tumors to identify candidate drivers of MPNST that can serve as therapeutic targets.