Gary D. Bader

Jul 10, 2024 | nature.com | Thomas Wälchli |Shigeki Takada |Hubert Rehrauer |Anuroopa Dinesh |Jeroen Bisschop |Fiona Farnhammer | +11 more

AbstractA broad range of brain pathologies critically relies on the vasculature, and cerebrovascular disease is a leading cause of death worldwide. However, the cellular and molecular architecture of the human brain vasculature remains incompletely understood1.

May 10, 2023 | nature.com | Yasin Mamatjan |Olivia Singh |Farshad Nassiri |Trevor J. Pugh |Gary D. Bader |Kenneth Aldape | +4 more

AbstractMalignant peripheral nerve sheath tumor (MPNST) is a highly aggressive sarcoma, and a lethal neurofibromatosis type 1-related malignancy, with little progress made on treatment strategies. Here, we apply a multiplatform integrated molecular analysis on 108 tumors spanning the spectrum of peripheral nerve sheath tumors to identify candidate drivers of MPNST that can serve as therapeutic targets.