Trevor J. Pugh

Toronto

Featured in: Favicon

nature.com Favicon

jamanetwork.com Favicon

elifesciences.org Favicon

aacrjournals.org Favicon

cancernetwork.com Favicon

cancerres.aacrjournals.org

Articles

Affirming the Feasibility of cfDNA Sequencing Use in Li-Fraumeni Syndrome

Oct 30, 2024 | cancernetwork.com | Trevor J. Pugh

Trevor Pugh, PhD, FACMG, spoke with CancerNetwork® at the 7th International Li-Fraumeni Syndrome (LFS) Association Symposium about the methodology and ongoing efforts associated with a prospective, controlled, randomized trial intended to assess the ability of cell-free DNA (cfDNA) sequencing to detect cancers in patients with LFS and similar cancer predisposition syndromes.1 In a presentation at the symposium, Pugh highlighted this trial as an initiative related to the cfDNA in Hereditary...
cfDNA Sequencing May Show Cancer Detection Benefits in Li-Fraumeni Syndrome

Oct 29, 2024 | cancernetwork.com | Trevor J. Pugh

In a conversation with CancerNetwork® at the 7th International Li-Fraumeni Syndrome (LFS) Association Symposium, Trevor Pugh, PhD, FACMG, spoke about research driving his presentation focusing on cell-free DNA (cfDNA) sequencing as a method for detecting cancer in patients with LFS and other hereditary cancer syndromes.1 Pugh and his colleagues are assessing the ability of cfDNA to potentially detect cancers early among this population in a prospective, randomized trial as part of the cfDNA...
Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment - Nature Communications

Apr 3, 2024 | nature.com | Jie Li |Christopher R Chin |Cem Meydan |Pedro Farinha |Yiyue Jiang |Martin Rivas | +9 more

AbstractDespite regulating overlapping gene enhancers and pathways, CREBBP and KMT2D mutations recurrently co-occur in germinal center (GC) B cell-derived lymphomas, suggesting potential oncogenic cooperation. Herein, we report that combined haploinsufficiency of Crebbp and Kmt2d induces a more severe mouse lymphoma phenotype (vs either allele alone) and unexpectedly confers an immune evasive microenvironment manifesting as CD8+ T-cell exhaustion and reduced infiltration.
Multiplatform molecular profiling uncovers two subgroups of malignant peripheral nerve sheath tumors with distinct therapeutic vulnerabilities - Nature Communications

May 10, 2023 | nature.com | Yasin Mamatjan |Olivia Singh |Farshad Nassiri |Trevor J. Pugh |Gary D. Bader |Kenneth Aldape | +4 more

AbstractMalignant peripheral nerve sheath tumor (MPNST) is a highly aggressive sarcoma, and a lethal neurofibromatosis type 1-related malignancy, with little progress made on treatment strategies. Here, we apply a multiplatform integrated molecular analysis on 108 tumors spanning the spectrum of peripheral nerve sheath tumors to identify candidate drivers of MPNST that can serve as therapeutic targets.