Felipe Cava

Jan 2, 2025 | nature.com | Dibya Saha |Gabriel Torrens |Mads Hansen |Kazuki Nosho |Hannah Jeckel |Stephan Göttig | +2 more

AbstractFor any organism, survival is enhanced by the ability to sense and respond to threats in advance. For bacteria, danger sensing among kin cells has been observed, but the presence or impacts of general danger signals are poorly understood. Here we show that different bacterial species use exogenous peptidoglycan fragments, which are released by nearby kin or non-kin cell lysis, as a general danger signal.

Jul 3, 2024 | nature.com | Gabriel Torrens |Rosa del Campo |André Mateus |Ana Rico |Felipe Cava |Ines Rodrigues-Lopes | +2 more

AbstractThe function of many bacterial processes depends on the formation of functional membrane microdomains (FMMs), which resemble the lipid rafts of eukaryotic cells. However, the mechanism and the biological function of these membrane microdomains remain unclear. Here, we show that FMMs in the pathogen methicillin-resistant Staphylococcus aureus (MRSA) are dedicated to confining and stabilizing proteins unfolded due to cellular stress.

Jun 16, 2024 | elpais.com | Felipe Cava

Ninguna vida cabe en un obituario. Y menos aún la de aquellos como Ludolfo Paramio, fallecido el pasado viernes, que cultivan unas veces el polifacetismo como un mecanismo de autodefensa y otras como una pulsión por apurar las muchas regalías del tiempo que les es dado permanecer junto a nosotros.

Feb 15, 2024 | biorxiv.org | Wei-Sheng W. Sun |Gabriel Torrens |Josy ter Beek |Felipe Cava

AbstractConjugative Type 4 Secretion Systems (T4SS) are a main driver for the spread of antibiotic resistance genes and virulence factors in bacteria. To deliver the DNA substrate to recipient cells, it must cross the cell envelopes of both donor and recipient mating bacteria. In the T4SS from the enterococcal conjugative plasmid pCF10, PrgK is known to be the active cell wall degrading enzyme. It has 3 predicted extracellular hydrolase domains, LytM, SLT and CHAP.