Florence Hardy

Mar 4, 2024 | nature.com | Florence Hardy |Linus O Johannissen |Richard Obexer |Sam Hay

AbstractDirected evolution of computationally designed enzymes has provided new insights into the emergence of sophisticated catalytic sites in proteins. In this regard, we have recently shown that a histidine nucleophile and a flexible arginine can work in synergy to accelerate the Morita-Baylis-Hillman (MBH) reaction with unrivalled efficiency.