Richard Obexer

Mar 21, 2024 | onlinelibrary.wiley.com | Richard Obexer

1 Introduction The universal genetic code defines the 20 standard proteinogenic amino acids (pAAs) and their ribosomal translation in response to their encoding trinucleotide sequences (codons). Despite the seemingly restricted number of pAAs and associated functional groups, the combinatorial possibilities are astronomical, which is reflected by the structural and functional diversity of the natural proteome.

Mar 4, 2024 | nature.com | Florence Hardy |Linus O Johannissen |Richard Obexer |Sam Hay

AbstractDirected evolution of computationally designed enzymes has provided new insights into the emergence of sophisticated catalytic sites in proteins. In this regard, we have recently shown that a histidine nucleophile and a flexible arginine can work in synergy to accelerate the Morita-Baylis-Hillman (MBH) reaction with unrivalled efficiency.