Florent Ginhoux

Sep 27, 2024 | nature.com | Florent Ginhoux

AbstractMacrophages are innate immune cells that are present in essentially all tissues, where they have vital roles in tissue development, homeostasis and pathogenesis. The importance of macrophages in tissue function is reflected by their association with various human diseases, and studying macrophage functions in both homeostasis and pathological tissue settings is a promising avenue for new targeted therapies that will improve human health.

Jul 21, 2024 | nature.com | Lu Pan |Florent Ginhoux

AbstractMyeloid cells are vital components of the immune system and have pivotal functions in orchestrating immune responses. Understanding their functions within the tumor microenvironment and their interactions with tumor-infiltrating lymphocytes presents formidable challenges across diverse cancer types, particularly with regards to cancer immunotherapies.

Jan 2, 2024 | nature.com | Ziyi Li |Zijie Zhang |Longqi Liu |Jacob George |Pierce Kah-Hoe Chow |Florent Ginhoux

AbstractOnco-fetal reprogramming of the tumor ecosystem induces fetal developmental signatures in the tumor microenvironment, leading to immunosuppressive features. Here, we employed single-cell RNA sequencing, spatial transcriptomics and bulk RNA sequencing to delineate specific cell subsets involved in hepatocellular carcinoma (HCC) relapse and response to immunotherapy.

Jul 10, 2023 | nature.com | Florent Ginhoux

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