Folkert W. Asselbergs

Oct 4, 2024 | nature.com | M. Louis Handoko |Susan Stienen |Marlies P. Schijven |Folkert W. Asselbergs |Aeilko H. Zwinderman

Correction to: Nature Medicine https://doi.org/10.1038/s41591-024-03238-6, published online 31 August 2024. In the version of the article initially published, the traces in Fig. 3 appeared with an incorrect 180° rotation, with y-axis units ranging from 0.5–1.0, rather than 0.0–0.5. The caption to Fig. 3, which originally read “The red Kaplan–Meier curve represents the time until OMT in the treatment group, and the blue curve represents the time until OMT in the usual care group.

Sep 14, 2024 | nature.com | Thorunn Olafsdottir |Gudmar Thorleifsson |Abhishek Niroula |Hannes P. Eggertsson |Gísli H. Halldórsson |Folkert W. Asselbergs | +9 more

AbstractImmunoglobulin G (IgG) is the main isotype of antibody in human blood. IgG consists of four subclasses (IgG1 to IgG4), encoded by separate constant region genes within the Ig heavy chain locus (IGH). Here, we report a genome-wide association study on blood IgG subclass levels. Across 4334 adults and 4571 individuals under 18 years, we discover ten new and identify four known variants at five loci influencing IgG subclass levels.

Aug 31, 2024 | nature.com | M. Louis Handoko |Susan Stienen |Marlies P. Schijven |Folkert W. Asselbergs |Aeilko H. Zwinderman

AbstractGuideline-directed medical therapy (GDMT) has clear benefits on morbidity and mortality in patients with heart failure; however, GDMT use remains low. In the multicenter, open-label, investigator-initiated ADMINISTER trial, patients (n = 150) diagnosed with heart failure and reduced ejection fraction (HFrEF) were randomized (1:1) to receive usual care or a strategy using digital consults (DCs).

Jul 22, 2024 | onlinelibrary.wiley.com | Teun Petersen |Navin Suthahar |Folkert W. Asselbergs |Marie de Bakker

What is already known? Heart failure (HF) is a heterogeneous condition with high mortality rates and increasing prevalence. Obesity is a risk factor for HF. Plasma levels of proteins linked to HF such as N-terminal pro-B-type natriuretic peptide (NT-proBNP) and C-reactive protein can be affected by obesity. What does this study add?

Apr 3, 2024 | medrxiv.org | Lovedeep Singh Dhingra |Arya Aminorroaya |Aline Pedroso Camargos |Folkert W. Asselbergs

Dr. Khera is an Associate Editor of JAMA. Dr. Khera and Mr. Sangha are the coinventors of U.S. Provisional Patent Application No. 63/346,610, "Articles and methods for format-independent detection of hidden cardiovascular disease from printed electrocardiographic images using deep learning" and are co-founders of Ensight-AI.