Frances Koback

Nov 29, 2023 | nature.com | Angelo Pelonero |Lin Ye |Michael Alexanian |Frances Koback |Casey A. Gifford

AbstractMaternal diabetes mellitus is among the most frequent environmental contributors to congenital birth defects, including heart defects and craniofacial anomalies, yet the cell types affected and mechanisms of disruption are largely unknown. Here, using multimodal single-cell analyses, we show that maternal diabetes affects the epigenomic landscape of specific subsets of cardiac and craniofacial progenitors during embryogenesis.