Francesca Polverino

2 months ago | healio.com | Isabella Hornick |Kristen Dowd |Francesca Polverino |Laura M. Paulin

Francesca Polverino, MD, PhD The findings of this study are not surprising, as the field of COPD research has increasingly shifted toward redefining the disease. Evidence now supports that pre- and peri-natal factors, along with childhood exposures, influence lung growth and contribute to the early development of fixed airflow limitation.

Jan 10, 2025 | digitalcommons.library.tmc.edu | Yohannes Tesfaigzi |Jeffrey Curtis |Irina Petrache |Francesca Polverino

KeywordsHumans, Endothelial Cells, Genome-Wide Association Study, Proteomics, Pulmonary Disease, Chronic Obstructive, Lung, lung cell types, single nucleotide polymorphisms, single-cell transcriptomics, lineage tracing, gene-and-environment interactionAbstractThe onset of chronic obstructive pulmonary disease (COPD) is heterogeneous, and current approaches to define distinct disease phenotypes are lacking.

Jan 10, 2025 | digitalcommons.library.tmc.edu | Francesca Polverino |Debra A. Stern |Eric Snyder |Courtney Wheatley-Guy

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May 28, 2024 | erj.ersjournals.com | Francesca Polverino |Don D. Sin

AbstractGlobally, nearly 400 million persons have COPD, and COPD is one of the leading causes of hospitalisation and mortality across the world. While it has been long-recognised that COPD is an inflammatory lung disease, dissimilar to asthma, type 2 inflammation was thought to play a minor role. However, recent studies suggest that in approximately one third of patients with COPD, type 2 inflammation may be an important driver of disease and a potential therapeutic target.

Mar 14, 2024 | erj.ersjournals.com | Francesca Polverino |Don D. Sin

FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.