Shuting Han

Sep 27, 2024 | biorxiv.org | Shuting Han |Fritjof Helmchen

AbstractThe coordinated changes of neural activity during learning, from single neurons to populations of neurons and their interactions across brain areas, remain poorly understood. To reveal specific learning-related changes, we applied multi-area two-photon calcium imaging in mouse neocortex during training of a sensory discrimination task. We uncovered coordinated adaptations in primary somatosensory area S1 and the anterior (A) and rostrolateral (RL) areas of posterior parietal cortex (PPC).

Sep 23, 2024 | biorxiv.org | Thomas Naert |Taiyo Yamamoto |Shuting Han |Melanie Horn

AbstractCRISPR-based genome engineering holds enormous promise for basic science and therapeutic applications. Integrating and editing DNA sequences is still challenging in many cellular contexts, largely due to insufficient control of the repair process. We find that repair at the genome-cargo interface is predictable by deep-learning models and adheres to sequence context specific rules.

Jan 4, 2024 | nature.com | Shuting Han |Fritjof Helmchen

AbstractAnimals adapt to a constantly changing world by predicting their environment and the consequences of their actions. The predictive coding hypothesis proposes that the brain generates predictions and continuously compares them with sensory inputs to guide behavior. However, how the brain reconciles conflicting top-down predictions and bottom-up sensory information remains unclear.