Gan Zhao

Oct 1, 2024 | nature.com | Lulu Xue |Gan Zhao |Ningqiang Gong |Xuexiang Han |Zebin Xiao |Junchao Xu | +11 more

AbstractSystemic delivery of messenger RNA (mRNA) for tissue-specific targeting using lipid nanoparticles (LNPs) holds great therapeutic potential. Nevertheless, how the structural characteristics of ionizable lipids (lipidoids) impact their capability to target cells and organs remains unclear.

Jul 9, 2024 | nature.com | Xuexiang Han |Ningqiang Gong |Lulu Xue |Majed Ghattas |Junchao Xu |Gan Zhao | +8 more

AbstractLipid nanoparticles (LNPs) are widely used for mRNA delivery, with cationic lipids greatly affecting biodistribution, cellular uptake, endosomal escape and transfection efficiency. However, the laborious synthesis of cationic lipids limits the discovery of efficacious candidates and slows down scale-up manufacturing.

Feb 25, 2024 | nature.com | Xuexiang Han |Junchao Xu |Ying Xu |Mohamad-Gabriel Alameh |Lulu Xue |Ningqiang Gong | +6 more

AbstractThe ionizable lipidoid is a key component of lipid nanoparticles (LNPs). Degradable lipidoids containing extended alkyl branches have received tremendous attention, yet their optimization and investigation are underappreciated. Here, we devise an in situ construction method for the combinatorial synthesis of degradable branched (DB) lipidoids.

Jan 4, 2024 | nature.com | Gan Zhao |Andrew Vaughan

AbstractMaintenance of the cellular boundary between airway and alveolar compartments during homeostasis and after injury is essential to prohibit pathological plasticity which can reduce respiratory function. Lung injury and disease can induce either functional alveolar epithelial regeneration or dysplastic formation of keratinized epithelium which does not efficiently contribute to gas exchange.