Majed Ghattas

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Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo - Nature Chemistry

Jul 9, 2024 | nature.com | Xuexiang Han |Ningqiang Gong |Lulu Xue |Majed Ghattas |Junchao Xu |Gan Zhao | +8 more

AbstractLipid nanoparticles (LNPs) are widely used for mRNA delivery, with cationic lipids greatly affecting biodistribution, cellular uptake, endosomal escape and transfection efficiency. However, the laborious synthesis of cationic lipids limits the discovery of efficacious candidates and slows down scale-up manufacturing.

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