Garrett S. Dunlap

Jun 11, 2024 | nature.com | Garrett S. Dunlap |Nida Meednu |Ruoqiao Wang |fan zhang |Anna Jonsson |Kevin H-C Wei | +11 more

AbstractRheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue and blood samples from 12 seropositive RA patients. We identify clonally expanded CD4 + T cells, including CCL5+ cells and T peripheral helper (Tph) cells, which show a prominent transcriptomic signature of recent activation and effector function.