Kevin H-C Wei

Nov 14, 2024 | nature.com | Ilya Korsunsky |William V Trim |Anna Jonsson |fan zhang |Kevin H-C Wei |Lydia Lynch

AbstractFibroblasts play critical roles in tissue homeostasis, but in pathologic states they can drive fibrosis, inflammation, and tissue destruction. Little is known about what regulates the homeostatic functions of fibroblasts. Here, we perform RNA sequencing and identify a gene expression program in healthy synovial fibroblasts characterized by enhanced fatty acid metabolism and lipid transport.

Jun 11, 2024 | nature.com | Garrett S. Dunlap |Nida Meednu |Ruoqiao Wang |fan zhang |Anna Jonsson |Kevin H-C Wei | +11 more

AbstractRheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue and blood samples from 12 seropositive RA patients. We identify clonally expanded CD4 + T cells, including CCL5+ cells and T peripheral helper (Tph) cells, which show a prominent transcriptomic signature of recent activation and effector function.

May 30, 2024 | nature.com | Kathryn Weinand |Saori Sakaue |Aparna Nathan |Anna Jonsson |fan zhang |Majd Al Suqri | +5 more

AbstractSynovial tissue inflammation is a hallmark of rheumatoid arthritis (RA). Recent work has identified prominent pathogenic cell states in inflamed RA synovial tissue, such as T peripheral helper cells; however, the epigenetic regulation of these states has yet to be defined. Here, we examine genome-wide open chromatin at single-cell resolution in 30 synovial tissue samples, including 12 samples with transcriptional data in multimodal experiments.

Dec 14, 2023 | nature.com | Jordan Brock |Kang Du |Kevin H-C Wei |Feng Shao |Scott Teresi |Kevin A Bird | +8 more

AbstractTeleost fishes, which are the largest and most diverse group of living vertebrates, have a rich history of ancient and recent polyploidy. Previous studies of allotetraploid common carp and goldfish (cyprinids) reported a dominant subgenome, which is more expressed and exhibits biased gene retention. However, the underlying mechanisms contributing to observed ‘subgenome dominance’ remains poorly understood.

Jul 4, 2023 | onlinelibrary.wiley.com | Pooja Prasad |Raj Nagappan |Brian Davidson |Kevin H-C Wei

Abstract Cardiac allograft vasculopathy (CAV) remains a common long-term complication of cardiac transplantation. While invasive coronary angiography is considered the gold standard, it is also invasive and lacks sensitivity to detect early, distal CAV. Although vasodilator stress myocardial contrast echocardiography perfusion imaging (MCE) is used in the detection of microvascular disease in non-transplant patients, there is little data guiding its use in transplant recipients.