Gautam Dey

May 22, 2024 | nature.com | Hiral Shah |Marine Olivetta |Chandni Bhickta |Paolo Ronchi |Eelco C. Tromer |Yannick Schwab | +4 more

Eukaryotes have evolved towards one of two extremes along a spectrum of strategies for remodelling the nuclear envelope during cell division: disassembling the nuclear envelope in an open mitosis or constructing an intranuclear spindle in a closed mitosis1,2. Both classes of mitotic remodelling involve key differences in the core division machinery but the evolutionary reasons for adopting a specific mechanism are unclear. Here we use an integrated comparative genomics and ultrastructural imaging approach to investigate mitotic strategies in Ichthyosporea, close relatives of animals and fungi. We show that species in this clade have diverged towards either a fungal-like closed mitosis or an animal-like open mitosis, probably to support distinct multinucleated or uninucleated states. Our results indicate that multinucleated life cycles favour the evolution of closed mitosis. We analyse cell division in ichthyosporeans and find that multinucleated life cycles favour the evolution of closed mitosis, in which the cell constructs a spindle within an intact nucleus.

Oct 25, 2023 | biorxiv.org | Jana Helsen |Hashim Reza |Gavin Sherlock |Gautam Dey

AbstractThe eukaryotic cell division machinery must rapidly and reproducibly duplicate and partition the cell's chromosomes in a carefully coordinated process. However, chromosome number varies dramatically between genomes, even on short evolutionary timescales. We sought to understand how the mitotic machinery senses and responds to karyotypic changes by using a set of budding yeast strains in which the native chromosomes have been successively fused.

Oct 4, 2023 | einpresswire.com | Gautam Dey

Dr. Anuraag Guglaani receiving Presidential Lifetime Achievement AwardDr. Anuraag Guglaani Receives "Presidential Lifetime Achievement Award" from the US President's OfficeWASHINGTON, DC, USA, October 4, 2023 / EINPresswire.com/ -- Dr. Anuraag Guglaani, a prominent figure in the field of Family Business Transformation and Expansion, has been honored with the prestigious "Presidential Lifetime Achievement Award" by the AmeriCorps and the Office of the US President.

Oct 2, 2023 | nature.com | Gautam Dey

ESCRT-III seals holes in the nuclear envelope (NE). A study now shows that the Cmp7-directed ESCRT-III cascade that grommets and reseals NE holes after spindle pole body (SPB) extrusion at the end of fission yeast mitosis is complemented by the presence of a proteinaceous diffusion barrier to ensure NE integrity. While the molecular sequence of events is well-defined for ESCRT-III recruitment in vitro8, it is less well-understood in the context of NE repair and sealing.

Jul 14, 2023 | disruptmagazine.com | Gautam Dey

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