Jana Helsen

Aug 8, 2024 | nature.com | Jana Helsen |Gavin Sherlock

AbstractThe eukaryotic cell division machinery must rapidly and reproducibly duplicate and partition the cell’s chromosomes in a carefully coordinated process. However, chromosome numbers vary dramatically between genomes, even on short evolutionary timescales. We sought to understand how the mitotic machinery senses and responds to karyotypic changes by using a series of budding yeast strains in which the native chromosomes have been successively fused.

Oct 25, 2023 | biorxiv.org | Jana Helsen |Hashim Reza |Gavin Sherlock |Gautam Dey

AbstractThe eukaryotic cell division machinery must rapidly and reproducibly duplicate and partition the cell's chromosomes in a carefully coordinated process. However, chromosome number varies dramatically between genomes, even on short evolutionary timescales. We sought to understand how the mitotic machinery senses and responds to karyotypic changes by using a set of budding yeast strains in which the native chromosomes have been successively fused.

May 13, 2023 | tinyurl.com | Jana Helsen |Gavin Sherlock

How did evolutionary processes shape cells, cellular processes, organelles, and proteins? How much cellular diversity is the result of adaptation? How have mutations, recombination, and genetic drift shaped cellular complexity? Does the evolutionary history of an organism (i.e., the mutations and cellular features it acquired along the way) contribute to future evolutionary trajectories? Do universal principles or regulatory networks underlie common processes?