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Dec 5, 2024 | 
journals.plos.org | Grant Kinsler |Yuping Li |Gavin Sherlock
Loading metrics Open Access Peer-reviewedResearch Article Citation: Kinsler G, Li Y, Sherlock G, Petrov DA (2024) A high-resolution two-step evolution experiment in yeast reveals a shift from pleiotropic to modular adaptation. PLoS Biol 22(12): e3002848. https://doi.org/10.1371/journal.pbio.3002848Academic Editor: J. Arjan G. M.
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Nov 26, 2024 | 
microbiologyresearch.org | Maria Luisa Granada |Emily Cook |Gavin Sherlock |Frank Rosenzweig
This article is part of the Microbe Profiles collection.
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References Anderson HW. Yeast-like fungi of the human intestinal tract. J Infect Dis 1917; 21:341–354 [View Article][Google Scholar] Kumar K, Askari F, Sahu MS, Kaur R. Candida glabrata: a lot more than meets the eye.
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Oct 3, 2024 | 
biorxiv.org | Jodi Lew-Smith |Gavin Sherlock |Jonathan Binkley
AbstractThe Candida Genome Database (CGD; www.candidagenome.org) is unique in being both a model organism database and a fungal pathogen database. As a fungal pathogen database, CGD hosts locus pages for five species of the best-studied pathogenic fungi in the Candida group. As a model organism database, the species Candida albicans serves as a model both for other Candida spp.
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Aug 8, 2024 | 
nature.com | Jana Helsen |Gavin Sherlock
AbstractThe eukaryotic cell division machinery must rapidly and reproducibly duplicate and partition the cell’s chromosomes in a carefully coordinated process. However, chromosome numbers vary dramatically between genomes, even on short evolutionary timescales. We sought to understand how the mitotic machinery senses and responds to karyotypic changes by using a series of budding yeast strains in which the native chromosomes have been successively fused.
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Apr 18, 2024 | 
biorxiv.org | Grant Kinsler |Yuping Li |Gavin Sherlock |Dmitri A. Petrov
AbstractEvolution by natural selection is expected to be a slow and gradual process. In particular, the mutations that drive evolution are predicted to be small and modular, incrementally improving a small number of traits. However, adaptive mutations identified early in microbial evolution experiments, cancer, and other systems often provide substantial fitness gains and pleiotropically improve multiple traits at once.
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Mar 20, 2024 | 
biorxiv.org | Danica T. Schmidtke |Angela Hickey |Ivan Liachko |Gavin Sherlock
AbstractThe prototypic crAssphage (Carjivirus communis) is one of the most abundant, prevalent, and persistent gut bacteriophages, yet it remains uncultured and its lifestyle uncharacterized. For the last decade, crAssphage has escaped plaque-dependent culturing efforts, leading us to investigate alternative lifestyles that might explain its widespread success. Through genomic analyses and culturing, we find that crAssphage uses a phage-plasmid lifestyle to persist extrachromosomally.
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Oct 25, 2023 | 
biorxiv.org | Jana Helsen |Hashim Reza |Gavin Sherlock |Gautam Dey
AbstractThe eukaryotic cell division machinery must rapidly and reproducibly duplicate and partition the cell's chromosomes in a carefully coordinated process. However, chromosome number varies dramatically between genomes, even on short evolutionary timescales. We sought to understand how the mitotic machinery senses and responds to karyotypic changes by using a set of budding yeast strains in which the native chromosomes have been successively fused.
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May 13, 2023 | 
tinyurl.com | Jana Helsen |Gavin Sherlock
How did evolutionary processes shape cells, cellular processes, organelles, and proteins? How much cellular diversity is the result of adaptation? How have mutations, recombination, and genetic drift shaped cellular complexity? Does the evolutionary history of an organism (i.e., the mutations and cellular features it acquired along the way) contribute to future evolutionary trajectories? Do universal principles or regulatory networks underlie common processes?
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May 6, 2023 | 
bmcgenomics.biomedcentral.com | Fangfei Li |Aditya Mahadevan |Gavin Sherlock
ReferencesGerrish PJ, Lenski RE. The fate of competing beneficial mutations in an asexual population. Genetica. 1998;102:127–44. Article PubMed Google Scholar Desai MM, Fisher DS. Beneficial mutation selection balance and the effect of linkage on positive selection. Genetics. 2007;176:1759–98. Article PubMed PubMed Central Google Scholar Park SC, Krug J. Clonal interference in large populations. Proc Natl Acad Sci U S A. 2007;104:18135–40.
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Apr 19, 2023 | 
nature.com | Leonid Kruglyak |Andreas M. Beyer |Joshua Bloom |Jan Grossbach |Gavin Sherlock
Authors and AffiliationsDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USALeonid Kruglyak & Joshua S. BloomDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USALeonid Kruglyak & Joshua S. BloomHoward Hughes Medical Institute, Chevy Chase, MD, USALeonid Kruglyak & Joshua S.
