Georg Nagel

Jan 9, 2025 | nature.com | Xiaodong Duan |Chong Zhang |Yujie Wu |Jun Ju |Oana M. Constantin |Yifan Pan | +6 more

AbstractOptogenetics is a valuable tool for studying the mechanisms of neurological diseases and is now being developed for therapeutic applications. In rodents and macaques, improved channelrhodopsins have been applied to achieve transcranial optogenetic stimulation. While transcranial photoexcitation of neurons has been achieved, noninvasive optogenetic inhibition for treating hyperexcitability-induced neurological disorders has remained elusive.

Aug 28, 2024 | nature.com | Meiqi Ding |Shang Yang |Sönke Scherzer |Martin J. Mueller |Rainer Hedrich |Georg Nagel | +2 more

AbstractEarly plant responses to different stress situations often encompass cytosolic Ca2+ increases, plasma membrane depolarization and the generation of reactive oxygen species1,2,3. However, the mechanisms by which these signalling elements are translated into defined physiological outcomes are poorly understood. Here, to study the basis for encoding of specificity in plant signal processing, we used light-gated ion channels (channelrhodopsins).