George A. Kuchel

Jan 6, 2025 | digitalcommons.library.tmc.edu | Daniel E. Forman |George A. Kuchel |John Newman |James Kirkland

Publication Date 8-15-2023 Journal Journal of the American College of Cardiology DOI 10.1016/j.jacc.2023.05.038 PubMedCentral® Posted Date 8-15-2024 PubMedCentral® Full Text Version Author MSS Published Open-Access yes Keywords Aged, Humans, Aging, Cardiovascular Diseases, Chronic Disease, Frailty, Geriatrics, Geroscience, frailty, geroscience, hallmarks, inflammation, multimorbidity Abstract Geroscience posits that cardiovascular disease (CVD) and other chronic diseases result from...

Sep 15, 2024 | nature.com | Jesse R. Poganik |Daniel Belsky |Joe LaCroix |Alan Cohen |Steven R. Cummings |Luigi Ferrucci | +15 more

AbstractBiomarkers of aging (BOA) are quantitative parameters that predict biological age and ideally its changes in response to interventions. In recent years, many promising molecular and omic BOA have emerged with an enormous potential for translational geroscience and improving healthspan. However, clinical translation remains limited, in part due to the gap between preclinical research and the application of BOA in clinical research and other translational settings.

Jun 2, 2024 | nature.com | Vidyani Suryadevara |Adam D. Hudgins |Alberto Pappalardo |Alla Karpova |Amit K. Dey |Birgit Schilling | +23 more

AbstractOnce considered a tissue culture-specific phenomenon, cellular senescence has now been linked to various biological processes with both beneficial and detrimental roles in humans, rodents and other species. Much of our understanding of senescent cell biology still originates from tissue culture studies, where each cell in the culture is driven to an irreversible cell cycle arrest.

Apr 22, 2024 | agsjournals.onlinelibrary.wiley.com | Tamara Tchkonia |Stephen B Kritchevsky |George A. Kuchel |James Kirkland

Aging processes are the leading risk factor for most serious diseases and disabilities across the lifespan including dementias, cancers, atherosclerosis, and frailty as well as impaired physical resilience to such stresses as infections, or surgery.1-3 Conditions related to fundamental aging mechanisms are the major drivers of morbidity, mortality, and health costs but have proven difficult to control.

Mar 3, 2024 | agsjournals.onlinelibrary.wiley.com | George A. Kuchel

In 2014, a new NIA U13 award allowed my colleagues and I, working closely with our NIA partners, to refocus the AGS/NIA Conference Series on three common geriatric syndromes1—delirium (2014), sleep disorders (2015), and urinary incontinence (2016).