George Biggs

Dec 4, 2024 | onlinelibrary.wiley.com | Harry Wilders |George Biggs |Jonathan Pettinger

Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.

Jul 25, 2024 | biorxiv.org | George Biggs |Emma E Cawood |Aini Vuorinen |William McCarthy

AbstractIdentifying pharmacological probes for human proteins represents a key opportunity to accelerate the discovery of new therapeutics. High-content screening approaches to expand the ligandable proteome offer the potential to expedite the discovery of novel chemical probes to study protein function.

Aug 14, 2023 | pubs.rsc.org | Alasdair Keith |Elizabeth Sawyer |Yuhang Xie |George Biggs

Combining Experiment and Energy Landscapes to Explore Anaerobic Heme Breakdown in Multifunctional Hemoproteins To survive, many pathogens extract heme from their host organism and break down the porphyrin scaffold to sequester the Fe2+ ion via a heme oxygenase. Recent studies have revealed that certain pathogens can anaerobically degrade heme.