George F. Gao

1 month ago | journalofinfection.com | George F. Gao

Keywords H10N5 avian influenza virus Clinical features Zoonosis Genetic tracing Phylodynamics Novel reassortant Introduction The H10Ny avian influenza viruses (AIVs) have been identified in various poultry and wild birds in Eurasia, the Americas, and Oceania since its first identification of H10N7 AIV isolates in chicken in Germany in 1949.1 The avian H10Ny AIVs showed high compatibility with different NA subtypes, thereof H10N1–H10N9 subtypes have been identified in avian hosts.2 Typically,...

2 months ago | onlinelibrary.wiley.com | Jun Liu |Prevention Beijing |Yan Wu |George F. Gao

Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description imr70000-sup-0001-TableS1.xlsxExcel 2007 spreadsheet , 2.8 MB Table S1. Amino acid substitutions and deletions in the representative SARS-CoV-2 variants/sub-variants. imr70000-sup-0002-TableS2.xlsxExcel 2007 spreadsheet , 57.7 KB Table S2. List of the epitopes of major anti-NTD mAbs. imr70000-sup-0003-TableS3.xlsxExcel 2007 spreadsheet , 74.8 KB Table S3.

Jun 11, 2024 | nature.com | Xi Wang |George F. Gao

AbstractThe herd immunity against SARS-CoV-2 is continuously consolidated across the world during the ongoing pandemic. However, the potential function of the nonconserved epitopes in the reverse preexisting cross-reactivity induced by SARS-CoV-2 to other human coronaviruses is not well explored.

May 12, 2024 | nature.com | George F. Gao

AbstractAlmost all the neutralizing antibodies targeting the receptor-binding domain (RBD) of spike (S) protein show weakened or lost efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged or emerging variants, such as Omicron and its sub-variants. This suggests that highly conserved epitopes are crucial for the development of neutralizing antibodies.

Aug 14, 2023 | thelancet.com | Cheeloo College |Beijing Institutes |George F. Gao

1Xu K Fan C Han Y Dai L Gao GF Immunogenicity, efficacy and safety of COVID-19 vaccines: an update of data published by 31 December 2021. Int Immunol. 34: 595-607 and the protein subunit vaccine ZF2001 (Anhui Zhifei Longcom, Hefei, China)2Dai L Gao L Tao L et al. Efficacy and safety of the RBD-dimer-based COVID-19 vaccine ZF2001 in adults. N Engl J Med.