Giampiero Valenzano

Dec 10, 2024 | prod--journal.elifesciences.org | Simei Go |Constantinos Demetriou |Sophie Hughes |Giampiero Valenzano

eLife assessment This valuable manuscript provides an interesting account documenting the role of resident CD56(br) NK cells in driving interaction with dendritic cells that attract CD8+ T cells to the pancreas cancer tumor microenvironment (TME). The work convincingly illustrates how irradiation combined with CCR5i and PD1 blockade leads to a reduction in pancreatic cancer growth that correlates with a reduction in Treg cells and enhancement of NK and CD8 T cells in the TME.