Constantinos Demetriou

Dec 10, 2024 | prod--journal.elifesciences.org | Simei Go |Constantinos Demetriou |Sophie Hughes |Giampiero Valenzano

eLife assessment This valuable manuscript provides an interesting account documenting the role of resident CD56(br) NK cells in driving interaction with dendritic cells that attract CD8+ T cells to the pancreas cancer tumor microenvironment (TME). The work convincingly illustrates how irradiation combined with CCR5i and PD1 blockade leads to a reduction in pancreatic cancer growth that correlates with a reduction in Treg cells and enhancement of NK and CD8 T cells in the TME.

Oct 18, 2023 | biorxiv.org | Simei Go |Sophie Hughes |Simone Lanfredini |Constantinos Demetriou

AbstractThe immunosuppressive microenvironment in PDAC prevents tumor control but strategies to restore anti-cancer immunology, by increasing CD8 T cell activity, have not been successful. Here we demonstrate how inducing localized physical damage using ionizing radiation (IR) unmasks the benefit of immunotherapy by increasing tissue-resident NK (trNK) cells that support CD8 T activity.