Gianluca Ursini

Nov 7, 2023 | nature.com | Laura A. Wortinger |Attila Szabó |Claudia Barth |Marianne Thoresen |Ole A. Andreassen |Srdjan Djurovic | +4 more

AbstractThe placenta plays a role in fetal brain development, and pregnancy and birth complications can be signs of placental dysfunction. Birth asphyxia is associated with smaller head size and higher risk of developing schizophrenia (SZ), but whether birth asphyxia and placental genomic risk factors associated with SZ are related and how they might impact brain development is unclear.

Oct 25, 2023 | nature.com | Gianluca Ursini |Xiaolei Zhu |Akira Sawa

AbstractAdolescent cannabis use increases the risk for cognitive impairments and psychiatric disorders. Cannabinoid receptor type 1 (Cnr1) is expressed not only in neurons and astrocytes, but also in microglia, which shape synaptic connections during adolescence. However, the role of microglia in mediating the adverse cognitive effects of delta-9-tetrahydrocannabinol (THC), the principal psychoactive constituent of cannabis, is not fully understood.

Jul 26, 2023 | biorxiv.org | Yuto Hasegawa |Juhyun Kim |Gianluca Ursini |Yan Jouroukhin

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May 15, 2023 | nature.com | Gianluca Ursini |Shizhong Han |Carmen J. Marsit |Ke Hao |Giovanna Punzi

AbstractOur earlier work has shown that genomic risk for schizophrenia converges with early life complications in affecting risk for the disorder and sex-biased neurodevelopmental trajectories. Here, we identify specific genes and potential mechanisms that, in placenta, may mediate such outcomes.