Giles Laboratory

Jul 9, 2024 | cell.com | Laurent Abel |Paris Sorbonne Cité |Giles Laboratory |Rockefeller Branch

SummaryRegardless of microbial virulence (i.e., the global infection-fatality ratio), age generally drives the prevalence of death from infection in unvaccinated humans. Four mortality patterns are recognized: the common U- and L-shaped curves of endemic infections and the unique W- and J-shaped curves of pandemic infections. We suggest that these patterns result from different sets of human genetic and immunological determinants.

Jan 9, 2024 | onlinelibrary.wiley.com | Paul Bastard |Paris Sorbonne Cité |Giles Laboratory |Pediatric Hematology-Immunology

1 INTRODUCTION Not all individuals exposed to any given pathogen become infected and the impact of infection is highly variable, from silent infection to lethal disease. Many historically lethal infections can now be prevented or cured with modern medicine.