Giles Laboratory

Jul 9, 2024 | cell.com | Laurent Abel |Paris Sorbonne Cité |Giles Laboratory |Rockefeller Branch

SummaryRegardless of microbial virulence (i.e., the global infection-fatality ratio), age generally drives the prevalence of death from infection in unvaccinated humans. Four mortality patterns are recognized: the common U- and L-shaped curves of endemic infections and the unique W- and J-shaped curves of pandemic infections. We suggest that these patterns result from different sets of human genetic and immunological determinants.

Jan 9, 2024 | onlinelibrary.wiley.com | Paul Bastard |Paris Sorbonne Cité |Giles Laboratory |Pediatric Hematology-Immunology

1 INTRODUCTION Not all individuals exposed to any given pathogen become infected and the impact of infection is highly variable, from silent infection to lethal disease. Many historically lethal infections can now be prevented or cured with modern medicine.

May 11, 2023 | frontiersin.org | Giles Laboratory |Paris Sorbonne Cité |Isabelle Meyts

Malgorzata Pac1*, Jean-Laurent Casanova2,3,4,5, Irina Tuzankina6 and László Maródi2,7 1Department of Immunology, The Children’s Memorial Health Institute, Warsaw, Poland 2St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY, United States 3Howard Hughes Medical Institute, New York, NY, United States 4Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Necker Hospital for Sick Children and Institut National de la Sante et de la...