Giuseppe Palumbo

Dec 12, 2024 | mdpi.com | Giuseppe Palumbo

1. IntroductionHematological emergencies encompass a range of acute, life-threatening conditions involving the blood, its components, or hematopoietic organs. These conditions demand immediate recognition and intervention.

Aug 14, 2024 | nature.com | Erika Tissino |Federico Pozzo |Francesca Rossi |Riccardo Bomben |Riccardo Moia |Giovanni D’Arena | +4 more

AbstractIn chronic lymphocytic leukemia (CLL), survival of neoplastic cells depends on microenvironmental signals at lymphoid sites where the crosstalk between the integrin VLA-4 (CD49d/CD29), expressed in ~40% of CLL, and the B-cell receptor (BCR) occurs. Here, BCR engagement inside–out activates VLA-4, thus enhancing VLA-4-mediated adhesion of CLL cells, which in turn obtain pro-survival signals from the surrounding microenvironment.

Dec 29, 2023 | acsjournals.onlinelibrary.wiley.com | Francesca Palandri |Giuseppe Palumbo |Giulia Benevolo |Alessandra Iurlo

INTRODUCTION Myelofibrosis (MF) is the most severe among the classical Philadelphia-negative myeloproliferative neoplasm (MPN), which may present de novo (primary myelofibrosis [PMF]) or secondary to essential thrombocythemia/polycythemia vera (PET/PPV-MF, SMF).1, 2 It is clinically characterized by splenomegaly, systemic symptoms, and progressive cytopenias.

May 3, 2023 | nature.com | Francesca Palandri |Massimiliano Bonifacio |Mario Tiribelli |Alessia Tieghi |Alessandra Iurlo |Nicola Polverelli | +8 more

IntroductionThe coronavirus disease 2019 (Covid19) pandemic caused by the spreading of the coronavirus SARS-CoV-2 has led to substantial mortality in patients with hematological diseases [1].