Gregory J. Brunette

Jun 7, 2023 | nature.com | Stamatis Papathanasiou |Gregory J. Brunette |Bas van Steensel |Jason D. Buenrostro |Cheng-Zhong Zhang

AbstractTranscriptional heterogeneity due to plasticity of the epigenetic state of chromatin contributes to tumour evolution, metastasis and drug resistance1,2,3. However, the mechanisms that cause this epigenetic variation are incompletely understood. Here we identify micronuclei and chromosome bridges, aberrations in the nucleus common in cancer4,5, as sources of heritable transcriptional suppression.