Cheng-Zhong Zhang

Aug 19, 2024 | biorxiv.org | Cheng-Zhong Zhang |David Pellman

AbstractDNA rearrangements are thought to arise from two classes of processes. The first class involves DNA breakage and fusion (cut-and-paste) without net DNA gain or loss. The second class involves aberrant DNA replication (copy-and-paste) and can produce either net DNA gain or loss.

Jun 7, 2023 | nature.com | Stamatis Papathanasiou |Gregory J. Brunette |Bas van Steensel |Jason D. Buenrostro |Cheng-Zhong Zhang

AbstractTranscriptional heterogeneity due to plasticity of the epigenetic state of chromatin contributes to tumour evolution, metastasis and drug resistance1,2,3. However, the mechanisms that cause this epigenetic variation are incompletely understood. Here we identify micronuclei and chromosome bridges, aberrations in the nucleus common in cancer4,5, as sources of heritable transcriptional suppression.