Guido Moll

Jul 5, 2023 | frontiersin.org | Kussmaul Campus |Deutsches Zentrum Immuntherapie |Friedrich-Alexander-University Erlangen-Nuremberg |Guido Moll

1 IntroductionGvHD (graft-versus-host diesase) is a common and severe complication after hematopoietic stem cell transplantation (HSCT) which affects up to 50% of patients and represents the primary cause of post-transplant mortality (1, 2). Pathomechanistically, donor T lymphocytes are considered to function as the central effector cell mediating GvHD development and progression.