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Jul 24, 2024 | 
academic.oup.com | Friedrich-Alexander-University Erlangen-Nuremberg
T cells are one of the main drivers of inflammatory bowel diseases (IBD). Infliximab (IFX) is used in the treatment of IBD as an anti-inflammatory drug to induce remission by neutralizing TNFα. We determined the individual chemokine/homing receptor and cytokine profile in pediatric IBD patients before and during IFX therapy to identify predictive biomarkers for therapy success.
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Feb 19, 2024 | 00060-6/fulltext?rss=yes&sz=64)
academicradiology.org | Mario Pasurka |Friedrich-Alexander-University Erlangen-Nuremberg |Theo Falck |Joshua Kubach
We hypothesized that there are differences regarding the in vivo elastic properties between the three tendons commonly used for ACLR and that they are influenced by several patient related factors. The hypotheses of our study were confirmed; the results of the current study revealed significant differences of the QT, PT and ST in terms of tissue elasticity measured by SWE. The most influencing factor on tendon elasticity was the physical activity level of the subjects.
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Dec 11, 2023 | 
ashpublications.org | Friedrich-Alexander-University Erlangen-Nuremberg |DRK-Blutspendedienst West
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment for high-risk hematologic diseases. However, even in graft-versus-host disease (GVHD)–free and relapse-free allo-HSCT survivors, full reconstitution of the adaptive immune system and functional protection from opportunistic infections can take months to years.
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Sep 5, 2023 | 
karger.com | Friedrich-Alexander-University Erlangen-Nuremberg |De Pretis |Stefano Francesco
Keywords:
Endoscopic ultrasound,
Pancreatitis,
Pancreatic cancer,
Endoscopic ultrasound-guided drainage,
Endoscopic ultrasound-guided biopsy
Endoscopic ultrasound (EUS) is a fundamental tool for diagnosis and therapeutic procedures in gastroenterology, hepatology, and pancreatology.
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Sep 5, 2023 | 
karger.com | Friedrich-Alexander-University Erlangen-Nuremberg
Keywords:
Endoscopic ultrasound,
Pancreatitis,
Pancreatic cancer,
Contrast-enhanced endoscopic ultrasound,
Elastometry
Endoscopic ultrasound (EUS) is a fundamental tool for the diagnosis as well as for therapeutic procedures in gastroenterology, hepatology, and pancreatology.
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Sep 4, 2023 | 
frontiersin.org | Justus Liebig |Friedrich-Alexander-University Erlangen-Nuremberg
1. IntroductionStudying the generation of new cells in the human brain is of fundamental importance, for at least two reasons. First, with regard to brain development, the generation of neurons is a key feature, and impairment of this process underlies various developmental disorders, notably microcephaly. Second, with regard to the maintenance of brain function, the ability to replace neurons is of pivotal relevance for aging research and regenerative medicine.
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Aug 30, 2023 | 
trialsjournal.biomedcentral.com | van Straten |Friedrich-Alexander-University Erlangen-Nuremberg |Vrije Universiteit Amsterdam |Lea K. J
It is crucial to keep in mind that clinical trial evaluations are an intricate topic and that this article barely scratches the surface. There is much more to learn about good practice in RCT analyses; a more in-depth and “hands-on” look at trial evaluations is provided in the tutorial in the supplement. Furthermore, many problems of RCTs arise at the design stage, well before the actual analysis.
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Jul 9, 2023 | 
onlinelibrary.wiley.com | Tamara M. Welte |Friedrich-Alexander-University Erlangen-Nuremberg |Sebastian Ernst |Jenny Stritzelberger
DISCUSSION In this large-scale retrospective study, we analysed 2791 patients who presented at a specialized nER in a tertiary care hospital in Germany. Ten years after a similar analysis including 1743 nER patients [6], our study still revealed a large proportion of patients presenting with non-acute symptoms without prior contact with health services and with no need for hospitalization.
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Jul 5, 2023 | 
frontiersin.org | Kussmaul Campus |Deutsches Zentrum Immuntherapie |Friedrich-Alexander-University Erlangen-Nuremberg |Guido Moll
1 IntroductionGvHD (graft-versus-host diesase) is a common and severe complication after hematopoietic stem cell transplantation (HSCT) which affects up to 50% of patients and represents the primary cause of post-transplant mortality (1, 2). Pathomechanistically, donor T lymphocytes are considered to function as the central effector cell mediating GvHD development and progression.
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Jun 27, 2023 | 
frontiersin.org | Friedrich-Alexander-University Erlangen-Nuremberg |Clinic Fürth
Thomas Bayer1*
Marie-Jo Brockhoff2
Armin M. Nagel3
Werner Adler4
Christoph Lutter5
Rolf Janka6
Rafael Heiss6
Michael Uder6
Frank W. Roemer6
1Institute of Neuroradiology and Radiology, Clinic Fürth, Germany
2Dept.
