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Jan 19, 2025 | 
link.springer.com | Universitätsklinikum Erlangen |Friedrich-Alexander-Universität Erlangen-Nürnberg |Deutsches Zentrum Immuntherapie
ZusammenfassungDie Pathophysiologie chronisch-entzündlicher Darmerkrankungen (CED) ist nicht vollständig geklärt. In einem Stufenmodell der European Crohn’s and Colitis Organisation (ECCO) zur Krankheitsentstehung wird von einem Risikopersonenkollektiv ausgegangen, in dem sich über subtile Veränderungen im Verlauf die Erkrankung manifestiert. Zusammenfassung des aktuellen Erkenntnisstands zur Pathophysiologie, Prädiktion und Prävention von CED. Selektive Literaturrecherche via PubMed.
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Aug 13, 2024 | 
link.springer.com | Friedrich-Alexander-Universität Erlangen-Nürnberg |Deutsches Zentrum Immuntherapie |Humboldt-Universität zu Berlin
AbstractPathogenic variants in the Cu/Zn superoxide dismutase (SOD1) gene can be detected in approximately 2% of sporadic and 11% of familial amyotrophic lateral sclerosis (ALS) patients in Europe. We analyzed the clinical phenotypes of 83 SOD1-ALS patients focusing on patients carrying the most frequent (likely) pathogenic variants (R116G, D91A, L145F) in Germany. Moreover, we describe the effect of tofersen treatment on ten patients carrying these variants.
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Jul 22, 2024 | 
academic.oup.com | Friedrich-Alexander-University Erlangen-Nürnberg |Universitätsklinikum Erlangen |Deutsches Zentrum Immuntherapie |Friedrich-Alexander Universität Erlangen-Nürnberg
Hypothesizing that early treatment yields improved prognosis, we aimed to investigate how the timing of immunosuppressive treatment relates to interstitial lung disease (ILD) development and the course of pulmonary function in systemic sclerosis (SSc).
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Dec 22, 2023 | 
academic.oup.com | Deutsches Zentrum Immuntherapie
Psoriasis is a chronic immune-mediated systemic disease that primarily affects the skin.1 Systemic inflammation in psoriasis is associated with a range of comorbidities, such as psoriatic arthritis (PsA), depression, metabolic syndrome and cardiovascular disease, as well as poor quality of life.2 Fumaric acid esters (FAE) have been used as a treatment for psoriasis since 1959 and remain a commonly prescribed first-line systemic therapy in Germany.3,4 Their effect is likely to be attributable...
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Dec 22, 2023 | 
academic.oup.com | Deutsches Zentrum Immuntherapie
The anti-interleukin-23 antibody guselkumab demonstrated favourable Week 24 efficacy and safety over fumaric acid esters (FAE) in systemic-treatment naïve patients with moderate-to-severe plaque psoriasis (study part I). Part II: compare a) sustainability of treatment responses (Weeks 24–32) in guselkumab- and FAE-treated patients and b) treatment responses (Weeks 32–56) in patients treated with guselkumab, FAE, and FAE non-responders switching to guselkumab.
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Dec 21, 2023 | 
academic.oup.com | Friedrich-Alexander-Universität Erlangen-Nürnberg |Universitätsklinikum Erlangen |Deutsches Zentrum Immuntherapie
Accepted manuscripts are PDF versions of the author’s final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting. They can be cited using the author(s), article title, journal title, year of online publication, and DOI. They will be replaced by the final typeset articles, which may therefore contain changes. The DOI will remain the same throughout.
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Sep 22, 2023 | 01126-1/fulltext?dgcid=twitter_organic_therapeutics_lancet&hss_channel=tw-27013292&sz=64)
thelancet.com | Georg Schett |Universitätsklinikum Erlangen |Deutsches Zentrum Immuntherapie |Andreas Mackensen
1. Wang L Wang FS Gershwin ME Human autoimmune diseases: a comprehensive update. J Intern Med. 2015; 278: 369-3952. Systemic lupus erythematosus. N Engl J Med. 2011; 365: 2110-21213. Schett G McInnes IB Neurath MF Reframing immune-mediated inflammatory diseases through signature cytokine hubs. N Engl J Med. 2021; 385: 628-6394. Fernando MM Stevens CR Walsh EC et al. Defining the role of the MHC in autoimmunity: a review and pooled analysis. PLoS Genet. 2008; 4e10000245.
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Sep 22, 2023 | 01126-1/fulltext&sz=64)
thelancet.com | Georg Schett |Universitätsklinikum Erlangen |Deutsches Zentrum Immuntherapie |Andreas Mackensen
1. Wang L Wang FS Gershwin ME Human autoimmune diseases: a comprehensive update. J Intern Med. 2015; 278: 369-3952. Systemic lupus erythematosus. N Engl J Med. 2011; 365: 2110-21213. Schett G McInnes IB Neurath MF Reframing immune-mediated inflammatory diseases through signature cytokine hubs. N Engl J Med. 2021; 385: 628-6394. Fernando MM Stevens CR Walsh EC et al. Defining the role of the MHC in autoimmunity: a review and pooled analysis. PLoS Genet. 2008; 4e10000245.
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Jul 8, 2023 | 
academic.oup.com | Friedrich-Alexander-University Erlangen-Nürnberg |Universitätsklinikum Erlangen |Deutsches Zentrum Immuntherapie |Friedrich-Alexander Universität Erlangen-Nürnberg
Interstitial lung disease (ILD) is the leading cause of mortality in systemic sclerosis (SSc). Novel biomarkers are crucial to improve outcomes in SSc-ILD. We aimed to compare the performance of potential serum biomarkers of SSc-ILD that reflect different pathogenic processes: KL-6 and SP-D (epithelial injury), CCL18 (type 2 immune response), YKL-40 (endothelial injury and matrix remodelling) and MMP-7 (ECM remodelling).
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Jul 5, 2023 | 
frontiersin.org | Kussmaul Campus |Deutsches Zentrum Immuntherapie |Friedrich-Alexander-University Erlangen-Nuremberg |Guido Moll
1 IntroductionGvHD (graft-versus-host diesase) is a common and severe complication after hematopoietic stem cell transplantation (HSCT) which affects up to 50% of patients and represents the primary cause of post-transplant mortality (1, 2). Pathomechanistically, donor T lymphocytes are considered to function as the central effector cell mediating GvHD development and progression.
