Guillermo Sastre-Moreno

Nov 6, 2024 | cell.com | Sumin Feng |Kaiwen Ivy Liu |Jinfeng Shang |Lisa Hoeg |William Yang |Guillermo Sastre-Moreno | +6 more

Keywords synthetic lethality DNA replication DNA replication fork ATP translocase genome stability simple repeats DNA double-strand breaks Introduction The human genome encodes 33 SNF2-family ATP-dependent translocases.1,2 While this family is generally viewed as consisting of chromatin remodeling enzymes, at least 11 of the 33 SNF2-family proteins (CHD1L, RAD54B, RAD54L, RAD54L2, HLTF, SHPRH, ERCC6, ERCC6L/PICH, ERCC6L2, SMARCAL1, and ZRANB3) are directly implicated in the maintenance of...