Kaiwen Ivy Liu

Nov 6, 2024 | cell.com | Sumin Feng |Kaiwen Ivy Liu |Jinfeng Shang |Lisa Hoeg |William Yang |Guillermo Sastre-Moreno | +6 more

Keywords synthetic lethality DNA replication DNA replication fork ATP translocase genome stability simple repeats DNA double-strand breaks Introduction The human genome encodes 33 SNF2-family ATP-dependent translocases.1,2 While this family is generally viewed as consisting of chromatin remodeling enzymes, at least 11 of the 33 SNF2-family proteins (CHD1L, RAD54B, RAD54L, RAD54L2, HLTF, SHPRH, ERCC6, ERCC6L/PICH, ERCC6L2, SMARCAL1, and ZRANB3) are directly implicated in the maintenance of...

Apr 19, 2024 | biorxiv.org | Amir Seyfoori |Kaiwen Ivy Liu |Hector J Caruncho |Patrick Walter

AbstractEmploying three-dimensional (3D) in vitro models, including tumor organoids and spheroids, stands pivotal in enhancing cancer therapy. These models bridge the gap between 2D cell cultures and complex in vivo environments, effectively mimicking the intricate cellular interplay and microenvironmental factors found in solid tumors. Consequently, they offer versatile tools for comprehensive studies into cancer progression, drug responses, and tailored therapies.

Feb 27, 2024 | biorxiv.org | Sumin Feng |Kaiwen Ivy Liu |Lisa Hoeg |Jinfeng Shang

AbstractDNA replication stress is a threat to genome integrity. The large SNF2-family of ATPases participates in preventing and mitigating DNA replication stress by employing their ATP-driven motor to remodel DNA or DNA-bound proteins. To understand the contribution of these ATPases in genome maintenance, we undertook CRISPR-based synthetic lethality screens with three SNF2-type ATPases: SMARCAL1, ZRANB3 and HLTF.

Sep 12, 2023 | mdpi.com | Kaiwen Ivy Liu |Hongbing Deng |Ting Wu |Yang Yi

2. Literature Review and Theoretical Hypothesis 2.1. The Influence Mechanism of Technological Innovation on Haze PollutionTechnological innovation is a significant driving force for promoting green and sustainable development, and plays a pivotal role in influencing efficient energy use developments [14]. Notably, green technological innovation contributes significantly to enhancing energy efficiency within the production process, leading to a total reduction in energy emissions [15,16].