Haiyang Hu

Jan 6, 2025 | nature.com | Haiyang Hu |Baohua Liu |Zhongyuan Wang

AbstractNucleotide availability is crucial for DNA replication and repair; however, the coordinating mechanisms in vivo remain unclear. Here, we show that the circadian clock in the liver controls the activity of the pentose phosphate pathway (PPP) to support de novo nucleotide biosynthesis for DNA synthesis demands. We demonstrate that disrupting the hepatic clock by genetic manipulation or mistimed feeding impairs PPP activity in male mice, leading to nucleotide imbalance.

Dec 5, 2024 | sciencedirect.com | Yan Gao |Haiyang Hu |Ben Sidders |S.B. Al Rihani

Section snippetsIntroduction to Plasmodium falciparum, breast cancer and therapeutic potential of oleuropeinThe human malaria parasite, Plasmodium falciparum, completes its life cycle within two hosts: a primary host (mosquitoes) and an intermediate host (humans). P.

Dec 4, 2024 | sciencedirect.com | Yan Gao |Haiyang Hu |Alexander Schuhmacher |Eloy Lozano baró

Section snippets Quality by design (QbD) implementation with nondestructive techniques According to the current good manufacturing practice (cGMP) requirements, the implementation of QbD methodologies coupled with process analytical technology (PAT) allows for efficient manufacturing of drug products with the desired quality for patient benefits (Figure 1, Figure 2).(p6) In the context of batch manufacturing of pharmaceutical drug products, the desired quality with net-zero loss is possible...

Aug 23, 2024 | mdpi.com | Yihan Li |Haiyang Hu |Qiang Wang

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