Zhongyuan Wang

Jan 6, 2025 | nature.com | Haiyang Hu |Baohua Liu |Zhongyuan Wang

AbstractNucleotide availability is crucial for DNA replication and repair; however, the coordinating mechanisms in vivo remain unclear. Here, we show that the circadian clock in the liver controls the activity of the pentose phosphate pathway (PPP) to support de novo nucleotide biosynthesis for DNA synthesis demands. We demonstrate that disrupting the hepatic clock by genetic manipulation or mistimed feeding impairs PPP activity in male mice, leading to nucleotide imbalance.

Oct 10, 2024 | onlinelibrary.wiley.com | Xiaofeng Li |Zhongyuan Wang |Shujuan Wang

CONFLICT OF INTEREST STATEMENT All authors declare that this research was implemented without any interest conflicts.

Jun 6, 2024 | mdpi.com | Qi Jiang |Yang Liu |Ying Zhou |Zhongyuan Wang

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Nov 15, 2023 | mdpi.com | Ruiguang Wang |Chao Hu |Zhongyuan Wang |Fang Yuan

All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.