Baohua Liu

1 month ago | mdpi.com | Juan Li |Baohua Liu |Caiyun Liu |Cong Lin

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Jan 6, 2025 | nature.com | Haiyang Hu |Baohua Liu |Zhongyuan Wang

AbstractNucleotide availability is crucial for DNA replication and repair; however, the coordinating mechanisms in vivo remain unclear. Here, we show that the circadian clock in the liver controls the activity of the pentose phosphate pathway (PPP) to support de novo nucleotide biosynthesis for DNA synthesis demands. We demonstrate that disrupting the hepatic clock by genetic manipulation or mistimed feeding impairs PPP activity in male mice, leading to nucleotide imbalance.

Aug 26, 2024 | mdpi.com | Baohua Liu |Hang Lin |Yifan Chen |Chaoyi Yang

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

Jun 22, 2023 | mdpi.com | Baohua Liu

Feb 9, 2023 | mdpi.com | Baohua Liu