Han-Yuan Liu

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Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism - Nature Communications

Jun 18, 2024 | nature.com | Han-Yuan Liu |Theresia Reindl |Ryan Golden |Katherine A. Donovan |Eric S. Fischer |Nathanael S. Gray

AbstractViral genetic diversity presents significant challenges in developing antivirals with broad-spectrum activity and high barriers to resistance. Here we report development of proteolysis targeting chimeras (PROTACs) targeting the dengue virus envelope (E) protein through coupling of known E fusion inhibitors to ligands of the CRL4CRBN E3 ubiquitin ligase.

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