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2 months ago | 
link.springer.com | Hangzhou Normal
AbstractWe study an M/M/1 queueing system with two stages and impatient customers. When affected by the external environment, customers in different stages have different levels of impatience. In stage 1, reneging is forbidden, while in stage 2, customers renege at an exponential rate. We mainly study the impact of the waiting space in stage 2 on customers’ decisions, system profit and social welfare. It is shown that the customers’ balking threshold is independent of the renege rate.
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2 months ago | 
link.springer.com | Hangzhou Normal
AbstractCurrent cancer treatments are known for their low selectivity, and life-threatening toxicity. To solve these issue, various innovative approaches were applied. One of them is the inhibition of DNA repair mechanisms, which have been developed as a new hotspot for its selective inhibition and low toxicity. Notably, PARP inhibition has shown potential for effective targeted cancer therapy.
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Jan 24, 2025 | 
link.springer.com | Haihe Laboratory |Tianjin Institutes |Hangzhou Normal
AbstractThe benefit of universal CAR-T cells over autologous CAR-T cell therapy is that they are a treatment that is ready to use. However, the prevention of graft-versus-host disease (GVHD) and host-versus-graft reaction (HVGR) remains challenging. Deleting class I of human leukocyte antigen (HLA-I) and class II of human leukocyte antigen (HLA-II) can prevent rejection by allogeneic T cells; however, natural killer (NK) cell rejection due to the loss of self-recognition remains unresolved.
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Jan 21, 2025 | 
cardiab.biomedcentral.com | Hangzhou Normal
Cardiovascular diseases (CVDs) are the leading cause of death worldwide and have a significant impact on the quality of life of patients. Common types of CVDs include myocardial infarction, coronary artery disease(CAD), stroke, and atherosclerosis [1]. Insulin resistance(IR) is a key factor in the development of type 2 diabetes and cardiovascular disease [2, 3].
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Jan 13, 2025 | 
equityhealthj.biomedcentral.com | Hangzhou Normal
Our study employed an ecologically controlled ITSA design, incorporating pre-intervention and post-intervention periods. To minimize time-varying confounding, Jinhua and Hangzhou were respectively set as intervention groups and compared with a control group not exposed to the intervention.
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Jan 13, 2025 | 
bmcpsychiatry.biomedcentral.com | Hangzhou Normal
The present study was conducted in accordance with the PRISMA 2020 guidelines [51], and the review protocol was registered on PROSPERO under the title “An updated review of social cognition in bipolar I and II disorders” (protocol number CRD42024575401). A search of the Web of Science and PubMed databases was conducted from inception to 28 August 2024 to identify studies that reported on the comparison of social cognition performance between BD I and BD II.
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Jan 9, 2025 | 
bmcpsychology.biomedcentral.com | Zhejiang Gongshang |Hangzhou Normal
We achieve the rendering of different color fonts (red, blue and black) by editing the font color in the Word document editing questionnaire. The font colors presented in this experiment are all pure colors (according to the RGB parameters): red (255.0.0), blue (0.0.255), and black (0,0,0). Shades of red and blue have been standardized, and the brightness and saturation of red and blue have been controlled.
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Jan 6, 2025 | 
bmcwomenshealth.biomedcentral.com | Hangzhou Normal
The data for this study were derived from the GBD 2021 study. The GBD has been systematically estimating mortality and health losses from a wide range of diseases using a standardized methodology since 1990, with re-estimations every 2–3 years [13, 14]. The GBD 2021 study provided estimates for the burden of disease attributable to 286 causes of death, 369 illnesses and injuries, and 87 risk factors across 204 countries and territories [15].
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Dec 2, 2024 | 
bmcpsychiatry.biomedcentral.com | Hangzhou Normal
This study was approved by the Medical Ethics Committee of Affiliated Xiaoshan Hospital, Hangzhou Normal University (Zhejiang Xiaoshan Hospital) (Approval NO. 2024–004). All procedures contributing to this work complied with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008.
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Nov 19, 2024 | 
academic.oup.com | Hangzhou Normal
BACKGROUND: Team-based delivery of family doctor services is associated with improved patient experiences, better health outcomes, and more efficient healthcare utilization. Team effectiveness is related to the team’s output, and family doctor team effectiveness (FDTE) directly impacts the quality and efficiency of contracted family doctor services.
