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Jan 24, 2025 | 
link.springer.com | Haihe Laboratory |Tianjin Institutes |Hangzhou Normal
AbstractThe benefit of universal CAR-T cells over autologous CAR-T cell therapy is that they are a treatment that is ready to use. However, the prevention of graft-versus-host disease (GVHD) and host-versus-graft reaction (HVGR) remains challenging. Deleting class I of human leukocyte antigen (HLA-I) and class II of human leukocyte antigen (HLA-II) can prevent rejection by allogeneic T cells; however, natural killer (NK) cell rejection due to the loss of self-recognition remains unresolved.
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Jan 22, 2025 | 
pubs.rsc.org | Yubo Li |Haihe Laboratory |Jinxia Wei |Jian Wang
Covalent organic frameworks as superior adsorbents for the removal of toxic substances†
Developing new materials capable of the safe and efficient removal of toxic substances has become a research hotspot in the field of materials science, as these toxic substances pose a serious threat to human health, both directly and indirectly.
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Jan 8, 2025 | 
bmcpsychiatry.biomedcentral.com | Haihe Laboratory |Tianjin Institutes
ReferencesParaskeva A, Theodosopoulou P. Major depressive disorder (MDD), antidepressants, and uncontrolled hypertension: A report of intraoperative autonomic dysregulation. Saudi J Anaesth. 2022;16(4):481–4. Article PubMed PubMed Central Google Scholar Dudek KA, et al. Neurobiology of resilience in depression: immune and vascular insights from human and animal studies. Eur J Neurosci. 2021;53(1):183–221. Article CAS PubMed Google Scholar Tran K, McGill SC, Horton J.
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Nov 29, 2024 | 
jneuroinflammation.biomedcentral.com | Haihe Laboratory
Patients with NMOSD (n = 15) and healthy controls (n = 15) were recruited from Tianjin Medical University General Hospital (Tianjin, China). Patients with NMOSD were diagnosed on the basis of the 2015 International Panel for Neuromyelitis Optica Diagnosis criteria [25]. Blood samples for flow cytometry were collected from patients during the acute phase of NMOSD. The participants in this study were matched for age and sex.
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Nov 28, 2024 | 
analyticalsciencejournals.onlinelibrary.wiley.com | Jiaxuan Chen |Haihe Laboratory |Yang Zhang
Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
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Sep 16, 2024 | 
academic.oup.com | Haihe Laboratory |Tianjin Institutes
CRISPR-Cas9 editing triggers activation of the TP53-p21 pathway, but the impacts of different editing components and delivery methods have not been fully explored. In this study, we introduce a p21-mNeonGreen reporter iPSC line to monitor TP53-p21 pathway activation. This reporter enables dynamic tracking of p21 expression via flow cytometry, revealing a strong correlation between p21 expression and indel frequencies, and highlighting its utility in guide RNA screening.
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Aug 9, 2024 | 
academic.oup.com | Haihe Laboratory
The emergence of drug-resistant pathogens represents a formidable challenge to global health. Using computational methods to identify the antibacterial peptides (ABPs), an alternative antimicrobial agent, has demonstrated advantages in further drug design studies. Most of the current approaches, however, rely on handcrafted features and underutilize structural information, which may affect prediction performance.
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Jul 25, 2024 | 
aacrjournals.org | Haihe Laboratory |Tianjin Institutes
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This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
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May 29, 2024 | 
academic.oup.com | Haihe Laboratory |Tianjin Institutes
Accepted manuscripts are PDF versions of the author’s final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting. They can be cited using the author(s), article title, journal title, year of online publication, and DOI. They will be replaced by the final typeset articles, which may therefore contain changes. The DOI will remain the same throughout. This content is only available as a PDF. © The Author(s) 2024.
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May 9, 2024 | 
academic.oup.com | Haihe Laboratory |Nini Wang
The maintenance of hematopoietic stem cells (HSCs) is a complex process involving numerous cell-extrinsic and -intrinsic regulators. The first member of the cyclin-dependent kinase family of inhibitors to be identified, p21, has been reported to perform a wide range of critical biological functions, including cell cycle regulation, transcription, differentiation, and so on.
