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Jan 24, 2025 | 
link.springer.com | Haihe Laboratory |Tianjin Institutes |Hangzhou Normal
AbstractThe benefit of universal CAR-T cells over autologous CAR-T cell therapy is that they are a treatment that is ready to use. However, the prevention of graft-versus-host disease (GVHD) and host-versus-graft reaction (HVGR) remains challenging. Deleting class I of human leukocyte antigen (HLA-I) and class II of human leukocyte antigen (HLA-II) can prevent rejection by allogeneic T cells; however, natural killer (NK) cell rejection due to the loss of self-recognition remains unresolved.
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Jan 8, 2025 | 
bmcpsychiatry.biomedcentral.com | Haihe Laboratory |Tianjin Institutes
ReferencesParaskeva A, Theodosopoulou P. Major depressive disorder (MDD), antidepressants, and uncontrolled hypertension: A report of intraoperative autonomic dysregulation. Saudi J Anaesth. 2022;16(4):481–4. Article PubMed PubMed Central Google Scholar Dudek KA, et al. Neurobiology of resilience in depression: immune and vascular insights from human and animal studies. Eur J Neurosci. 2021;53(1):183–221. Article CAS PubMed Google Scholar Tran K, McGill SC, Horton J.
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Oct 2, 2024 | 
onlinelibrary.wiley.com | Ping Li |Wei Liu |Tianjin Institutes |Lili Zhou
1 INTRODUCTION Since 2017, several chimeric antigen receptor (CAR)-T therapies targeting CD19 have been approved, including tisagenlecleucel, axicabtagene ciloleucel (axi-cel), lisocabtagene maraleucel (liso-cel) and relmacabtagene autoleucel, marking important milestones for the treatment of large B-cell lymphoma (LBCL).
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Sep 16, 2024 | 
academic.oup.com | Haihe Laboratory |Tianjin Institutes
CRISPR-Cas9 editing triggers activation of the TP53-p21 pathway, but the impacts of different editing components and delivery methods have not been fully explored. In this study, we introduce a p21-mNeonGreen reporter iPSC line to monitor TP53-p21 pathway activation. This reporter enables dynamic tracking of p21 expression via flow cytometry, revealing a strong correlation between p21 expression and indel frequencies, and highlighting its utility in guide RNA screening.
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Jul 25, 2024 | 
aacrjournals.org | Haihe Laboratory |Tianjin Institutes
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This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
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May 29, 2024 | 
academic.oup.com | Haihe Laboratory |Tianjin Institutes
Accepted manuscripts are PDF versions of the author’s final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting. They can be cited using the author(s), article title, journal title, year of online publication, and DOI. They will be replaced by the final typeset articles, which may therefore contain changes. The DOI will remain the same throughout. This content is only available as a PDF. © The Author(s) 2024.
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Apr 3, 2024 | 
onlinelibrary.wiley.com | Huyen Tran |Renchi Yang |Haihe Laboratory |Tianjin Institutes
CONFLICT OF INTEREST STATEMENT HT has acted as a consultant to CSL Behring, Roche, Pifzer. RY has received speaker/consultancy fees from Novo Nordisk, Pfizer, Roche, Sanofi, Takeda. KF has acted as a consultant and participated in expert groups for Bayer, Biogen, CSL Behring, NovoNordisk, and Sobi, has received research grants from Bayer, NovoNordisk, Pfizer, and has given invited educational lectures for Bayer, NovoNordisk, and Pfizer, and has received travel support from Sobi and Bayer.
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Mar 21, 2024 | 
onlinelibrary.wiley.com | Ting Sun |Haihe Laboratory |Tianjin Institutes
CONFLICT OF INTEREST STATEMENT The authors declare no competing financial interests. Supporting Information Filename Description bjh19420-sup-0001-Supinfo.docxWord 2007 document , 3 MB Data S1. REFERENCES 1, , . How we treat primary immune thrombocytopenia in adults. J Hematol Oncol. 2023; 16(1): 4. 2, , , , , , et al. Splenectomy for primary immune thrombocytopenia revisited in the era of thrombopoietin receptor agonists: new insights for an old treatment.
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Mar 15, 2024 | 
aacrjournals.org | Haihe Laboratory |Tianjin Institutes
H. Fan: Conceptualization, data curation, formal analysis, investigation, visualization, methodology, writing–original draft, writing–review and editing. B. Wang: Conceptualization, resources, data curation, formal analysis, supervision, investigation, visualization, methodology, writing–original draft, writing–review and editing. L. Shi: Data curation. N. Pan: Data curation, software, formal analysis. W. Yan: Data curation. J. Xu: Data curation, software. L. Gong: Data curation, software. L.
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Mar 4, 2024 | 
onlinelibrary.wiley.com | Haihe Laboratory |Tianjin Institutes |Ting Sun
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest that pertain to this work. Supporting Information Filename Description bjh19391-sup-0001-TableS1.xlsxExcel 2007 spreadsheet , 96.1 KB Table S1. bjh19391-sup-0002-Supinfo.docxWord 2007 document , 2.5 MB Data S1. REFERENCES 1, , , . Abnormalities of the bone marrow immune microenvironment in patients with immune thrombocytopenia. Ann Hematol. 2016; 95: 959–965.
