Yao Lu

Jan 23, 2025 | insight.jci.org | JCI Insight |Sudarshan Bhattacharjee |Jianing Gao |Yao Lu

AbstractDiabetes mellitus can cause impaired and delayed wound healing, leading to lower extremity amputations; however, the mechanisms underlying the regulation of vascular endothelial growth factor–dependent (VEGF-dependent) angiogenesis remain unclear. In our study, the molecular underpinnings of endothelial dysfunction in diabetes are investigated, focusing on the roles of disabled-2 (Dab2) and Forkhead box M1 (FOXM1) in VEGF receptor 2 (VEGFR2) signaling and endothelial cell function.

Jan 7, 2025 | cell.com | Jessica D. Ewald |Yao Lu |Cara E. Ellis |Jessica Worton |Jelena Kolic |Shugo Sasaki | +25 more

ForumVolume 37, Issue 1p7-11 1Institute of Parasitology, McGill University, Montreal, QC, Canada 2Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA 3Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada 4Department of Pharmacology, University of Alberta, Edmonton, AB, Canada 5Department of Surgery, University of Alberta, Edmonton, AB, Canada 6Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia,...

Jan 7, 2025 | cell.com | Jessica D. Ewald |Yao Lu |Cara E. Ellis |Jessica Worton |Jelena Kolic |Shugo Sasaki | +25 more

ForumVolume 37, Issue 1p7-11 1Institute of Parasitology, McGill University, Montreal, QC, Canada 2Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA 3Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada 4Department of Pharmacology, University of Alberta, Edmonton, AB, Canada 5Department of Surgery, University of Alberta, Edmonton, AB, Canada 6Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia,...

Jan 7, 2025 | pubs.rsc.org | Juan Li |Xiuyan Zhao |Yutao Zhang |Yao Lu

Two-Dimensional Fluorescence and Chemiluminescence Orthogonal Probe for Discriminating and Quantifying Similar Proteins Given that proteins with minor variations in amino acid sequences cause distinct functional outcomes, identifying and quantifying similar proteins is crucial, but remains a long-standing challenge.

Jan 6, 2025 | mdpi.com | Yao Lu

1. IntroductionMammography is a procedure that uses low-energy X-rays to photograph the breast and is widely used for the early screening and diagnosis of breast cancer. The breast border, the nipple, and the pectoral muscle are three important anatomical markers on mammograms [,]. Specifically, the pectoral muscle is usually identified first in mammography-based screening and diagnosis.