Helen Forgham

Jan 15, 2025 | biorxiv.org | Ibrahim Javed |Thomas Davis |Helen Forgham |Eduardo A. Albornoz

AbstractGut bacteria have emerged as silent drivers in the pathology of Alzheimers disease (AD). They also make amyloids with structure analogue to pathological amyloids and have potential to cross-seed and propagate in a prion-like manner. AD is characterised by the accumulation of mature extracellular Amyloid-β (Aβ) plaques which are surrounded by inflammatory microglia.

Apr 22, 2024 | onlinelibrary.wiley.com | Helen Forgham |Nanotechnology The |Jiayuan Zhu |Xumin Huang

1 Introduction Medulloblastoma is the most diagnosed malignant form of brain cancer in children.[1] Although improvements in treatment over the last few decades have helped to increase survival, medulloblastoma and other brain cancer subtypes collectively take the lives of more children and adults under the age of 40 than any other cancer.

Aug 18, 2023 | onlinelibrary.wiley.com | syed Ali |Nanotechnology The |Helen Forgham |William Olsen

1 Introduction Amyloid-β (Aβ) is a peptide generated from the proteolytic cleavage of amyloid precursor protein (APP) expressed on the membrane and synapses of neurons.